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Acute generalized eruptive pustulosis clinical analysis of 8 cases

Reported 63 cases of AGEP in a rash of 55 cases before the medication history, of which 45 cases of antibiotics,[link widoczny dla zalogowanych], it may have a variety of drug-induced induced non-specific trauma caused by a reaction of the same form. 1997 Kuchlert,[link widoczny dla zalogowanych], and other services reported 3 cases occurred after nystatin AGEP, AGEP induced by the acetaminophen H】 also reported in a foreign country, recently reported that there are metronidazole, indicating the occurrence of AGEP drugs significantly About: Left ~ ( 1966 -), female, Huadian City, Jilin Province, who,[link widoczny dla zalogowanych], bachelor, associate chief physicians, mainly engaged in studies of drug allergies. Every time is short, often no more than 1d, antibiotics, antibiotic induced lesions than non-significantly shorter incubation period, the former an average of 2.5d, which 18d. Common antibiotics and drugs for the shrine heat pain medicines. 8 cases in our department statistics, medication history in 7 cases, the lesions were appeared within 48h after treatment, the fastest 6h rash, the average 23.4h. Clinically, AGEP and generalized pustular psoriasis GPP easily confused, the differential diagnosis of the following characteristics: (~) AGEP no history of psoriasis, the majority have medication history. ② onset often accompanied by fever,[link widoczny dla zalogowanych], but no joint symptoms, although no difference in body temperature in patients with GPP, but the shorter duration of fever, an average of 7d, while the GPP fever of long duration, an average of about 16d, and often accompanied by joint pain. ③ pustular rash is mainly, but may be associated with purpura, erythema, swelling and other damage,[link widoczny dla zalogowanych], short duration of pustules GPP longer. ④ While both of which are pathological epidermal spongiform pustules, but AGEP has obvious papillary edema and vasculitis skin changes, no significant acanthosis, while the GPP acanthosis obvious change without vasculitis. (~) AGEP patients after removal of incentives for self-healing, after the little relapse, while patients were cured after GPP recurrence rate is high. Because AGEP obviously self-limiting, so treatment is mainly to symptomatic treatment. Although we take two different approaches to treatment, but both the mean fever clearance time, pustular rash, dry time and no significant difference in terms of fade time. In summary AGEP has the following characteristics: ① most drug-related; ② abrupt onset, most of <24h; ③ mostly edematous erythema appeared on the basis of large pustules tip diameter <5cm, more than the number of pustules; ④ fever more in the 38 ~ (21) 1h; ⑤ peripheral leukocytosis; ⑥ disease control 8d about the rash can be spontaneous regression, the course is not more than 2 weeks; ⑦ Corner pathology that under the pustules. 3
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